Selective oestrogen receptor modulators (SERMs)
نویسندگان
چکیده
منابع مشابه
Selective estrogen receptor modulators (SERMS).
Hormone receptors and, specifically, estrogen receptors were described about four decades ago. For estrogens, there are two receptors, estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta). The two receptors are coded by different genes and their tissue expression varies across organs. ERalpha is predominantly expressed in reproductive tissues (uterus, breast, ovaries) liver and...
متن کاملNew Selective Estrogen Receptor Modulators (SERMs) in Development
Selective estrogen receptor modulators (SERMs) or estrogen agonists/antagonists have shown promise in osteoporosis in that they have the potential to reduce the risk of fracture, and also reduce the risk of breast cancer. SERMs maybe classified according to their core structure, which is typically a variation of the 17 beta-estradiol template and subclassified according to the side chain at the...
متن کاملSelective oestrogen receptor modulators/new antioestrogens: a clinical perspective.
Following tamoxifen, the first selective oestrogen receptor modulator (SERM), a number of other antioestrogens have been developed. The first-generation SERMs exhibit cross-resistance with tamoxifen and have agonist effects on the uterus. Toremifene has equal efficacy to tamoxifen and may be useful as a tamoxifen alternative. Efficacy results for droloxifene and idoxifene were disappointing and...
متن کاملA pharmacological review of selective oestrogen receptor modulators.
Selective oestrogen receptor modulators (SERMs) are structurally diverse non-steroidal compounds that bind to oestrogen receptors and produce oestrogen agonist effects in some tissues and oestrogen antagonist effects in others. SERMs are being evaluated for a number of oestrogen-related diseases, including post-menopausal osteoporosis, hormone-dependent cancers, and cardiovascular disease. Seve...
متن کاملBotanic Selective Estrogen Receptor Modulators (SERMs) and Venous Thrombo Emboli (VTE)
Botanic Selective Estrogen Receptor Modulators (SERMs) and Venous Thrombo Emboli (VTE) Arnon Blum1*, Shira Shoher1, Andrei Adler2, Doron Ben David2, Shay Yeganeh1 1Department of Medicine Baruch Padeh Poria Hsopital Bar Ilan University, Israel 2Department of Imaging, Baruch Padeh Poria Hsopital Bar Ilan University, Israel *Corresponding author: Dr. Arnon Blum, Department of Medicine, Baruch Pade...
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ژورنال
عنوان ژورنال: The Obstetrician & Gynaecologist
سال: 2000
ISSN: 1467-2561
DOI: 10.1576/toag.2000.2.1.6